博后招聘：干细胞和重组细胞中染色质功能和结构研究方向，PiaCosma课题组,中国科学院广州生物医药与健康研究院

中国科学院广州生物医药与健康研究院Cosma课题组拟招聘2位积极性高，在生物医学、生物物理学或相关学科有丰富知识经验的科研人员。博士学历者为佳，在细胞培养和显微镜学方面有经验者为佳。优先考虑在高分辨率显微镜或CRISPR/Cas等方面有经验者。成功应聘者有机会在广州生物院工作前派往西班牙巴塞罗那CRG接受STORM显微镜学培训。

条件：

本职位拟招博士后，将提供满足在巴塞罗那或广州生活并且具有竞争力的工资。

申请流程：

应聘者请将相关资料发送给PiaCosma教授：英文CV中请附加详细联系方式，自荐信及2-3份推荐信（英文，附带联系人方式）。请将应聘资料发送至pia.cosma@crg.eu，邮件标题注明：应聘某某岗位+本人姓名+教育科研人才网。

本职位应聘长期开放，应聘成功者能尽快到任为佳。

广州生物院简介：http://www.gibh.cas.cn/

课题组简介：

Reprogramming and Regeneration Laboratory

Pia Cosma’s group is an internationally recognized laboratory (http://piacosmalab.com/) and will start at GIBH in August 2018. The group has as main objective to investigate the mechanisms controlling the reprogramming of somatic cells, and to determine if this reprogramming contributes to tissue regeneration in higher vertebrates. Cosma’s group has discovered that activation of the Wnt/β-catenin signalling pathway enhances cell-fusion-mediated reprogramming of somatic cells and studied extensively the mechanism behind (Lluis et al., Cell Stem Cell 2008; Stem Cells 2010; PNAS 2011; Aulicino et al., Stem Cell Report 2014; Marucci et al. Cell Reports 2014; De Jaime-Soguero et al. Plos Genetics 2017, Frade et al. Nature Cell Biology, under revision). Cosma’s group demonstrated that regeneration of the retina, dopaminergic neurons in Parkinson’s disease and of liver after hepatectomy is possible via Wnt controlled cell-fusion-mediated reprogramming (Sanges et al., Cell Reports 2013; J. of Clinical Investigation 2016; Pesaresi et al. eBioMedicine 2018; Altarche-Xifro’ eBioMedicine 2016; Pedone et al., Cell Reports 2017).

In addition, Cosma’s Group has a long interest in studying gene and chromatin function (Cantone et al, Cell 2009). Recently using super resolution microscopy (STORM), the group has identified a new model of chromatin fiber assembly and how the fiber changes in somatic and embryonic stem cells (Ricci et al. Cell 2015, Neguembor et al., NAR 2017).

We are currently studying the changes in chromatin structure and organization during somatic cell reprogramming and differentiation, to determine how chromatin fibers can be rearranged to overcome epigenetic barriers to gain pluripotency.

原文出处：

http://www.gibh.cas.cn/rczp/ypxx/201809/t20180903_5062012.html

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